3OG7
B-Raf Kinase V600E oncogenic mutant in complex with PLX4032
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | AKAP9-BRAF fusion protein | polymer | 289 | 32977.7 | 2 | UniProt (Q5IBP5) Pfam (PF07714) UniProt (by SIFTS) (P15056) In PDB | Homo sapiens (human) | Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1 |
2 | A | N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | non-polymer | 489.9 | 1 | Chemie (032) | |||
3 | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
A, B: 449 - 720 (UniProt: Q5IBP5)
PDB | External Database | Details |
---|---|---|
Met 432 | - | expression tag |
Lys 433 | - | expression tag |
Lys 434 | - | expression tag |
Gly 435 | - | expression tag |
His 436 | - | expression tag |
His 437 | - | expression tag |
His 438 | - | expression tag |
His 439 | - | expression tag |
His 440 | - | expression tag |
His 441 | - | expression tag |
Gly 442 | - | expression tag |
Ser 443 | - | expression tag |
Arg 444 | - | expression tag |
Asp 445 | - | expression tag |
Ala 446 | - | expression tag |
Ala 447 | - | expression tag |
Asp 448 | - | expression tag |
Ala 522 | Lys 1248 | engineered mutation |
Ala 543 | Ile 1269 | engineered mutation |
Ser 544 | Ile 1270 | engineered mutation |
Lys 551 | Ile 1277 | engineered mutation |
Arg 562 | Gln 1288 | engineered mutation |
Asn 588 | Leu 1314 | engineered mutation |
Glu 600 | Val 1326 | variant |
Ser 630 | Lys 1356 | engineered mutation |
Glu 667 | Phe 1393 | engineered mutation |
Ser 673 | Tyr 1399 | engineered mutation |
Arg 688 | Ala 1414 | engineered mutation |
Ser 706 | Leu 1432 | engineered mutation |
Arg 709 | Gln 1435 | engineered mutation |
Glu 713 | Ser 1439 | engineered mutation |
Glu 716 | Leu 1442 | engineered mutation |
Glu 720 | Ser 1446 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 65955.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 489.9 | |
All* | Total formula weight | 66445.4 |