Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3ME3

Activator-Bound Structure of Human Pyruvate Kinase M2

Summary for 3ME3
Entry DOI10.2210/pdb3me3/pdb
DescriptorPyruvate kinase isozymes M1/M2, 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (6 entities in total)
Functional Keywordsactivator, structural genomics consortium, sgc, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains4
Total formula weight242852.19
Authors
Primary citationAnastasiou, D.,Yu, Y.,Israelsen, W.J.,Jiang, J.K.,Boxer, M.B.,Hong, B.S.,Tempel, W.,Dimov, S.,Shen, M.,Jha, A.,Yang, H.,Mattaini, K.R.,Metallo, C.M.,Fiske, B.P.,Courtney, K.D.,Malstrom, S.,Khan, T.M.,Kung, C.,Skoumbourdis, A.P.,Veith, H.,Southall, N.,Walsh, M.J.,Brimacombe, K.R.,Leister, W.,Lunt, S.Y.,Johnson, Z.R.,Yen, K.E.,Kunii, K.,Davidson, S.M.,Christofk, H.R.,Austin, C.P.,Inglese, J.,Harris, M.H.,Asara, J.M.,Stephanopoulos, G.,Salituro, F.G.,Jin, S.,Dang, L.,Auld, D.S.,Park, H.W.,Cantley, L.C.,Thomas, C.J.,Vander Heiden, M.G.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8:839-847, 2012
Cited by
PubMed: 22922757
DOI: 10.1038/nchembio.1060
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon