3ME3
Activator-Bound Structure of Human Pyruvate Kinase M2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase isozymes M1/M2 | polymer | 550 | 60050.1 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Pyruvate kinase muscle isozyme, Pyruvate kinase 2/3, Cytosolic thyroid hormone-binding protein, CTHBP, Thyroid hormone-binding protein 1, THBP1, Opa-interacting protein 3, OIP-3, p58, Tumor M2-PK |
| 2 | E, UA (A, D) | 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline | non-polymer | 453.5 | 2 | Chemie (3SZ) PubChem (44543605) | |||
| 3 | F, HA, V, VA (A, C, B, D) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) PubChem (16219368) PubChem (718) PubChem (10267) PubChem (172313) PubChem (24802138) PubChem (440117) PubChem (46937007) PubChem (5702629) PubChem (89534552) PubChem (445557) PubChem (92209485) PubChem (92209486) PubChem (12800340) PubChem (92209487) PubChem (124383956) PubChem (124540446) PubChem (135053794) PubChem (123134048) PubChem (124202619) PubChem (124427861) PubChem (124524513) PubChem (124604817) PubChem (130233858) PubChem (133126640) PubChem (135055131) PubChem (140434362) PubChem (146159004) PubChem (160510795) | |||
| 4 | G, IA, W, WA (A, C, B, D) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | AA, AB, BA, BB, CA... (B, D, A, C) | UNKNOWN ATOM OR ION | non-polymer | 42 | Chemie (UNX) | ||||
| 6 | EB, FB, GB, HB (A, B, C, D) | water | water | 18.0 | 675 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Met -18 | - | expression tag |
| Gly -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ser -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 240200.4 | |
| Non-Polymers* | Number of molecules | 52 |
| Total formula weight | 2651.8 | |
| All* | Total formula weight | 242852.2 |
