3HVT
STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER
Replaces: 2HVTReplaces: 1HVTSummary for 3HVT
Entry DOI | 10.2210/pdb3hvt/pdb |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66), HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P51), 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE (3 entities in total) |
Functional Keywords | nucleotidyltransferase |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 114326.18 |
Authors | Steitz, T.A.,Smerdon, S.J.,Jaeger, J.,Wang, J.,Kohlstaedt, L.A.,Chirino, A.J.,Friedman, J.M.,Rice, P.A. (deposition date: 1994-07-25, release date: 1994-10-15, Last modification date: 2024-02-21) |
Primary citation | Smerdon, S.J.,Jager, J.,Wang, J.,Kohlstaedt, L.A.,Chirino, A.J.,Friedman, J.M.,Rice, P.A.,Steitz, T.A. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc.Natl.Acad.Sci.Usa, 91:3911-3915, 1994 Cited by PubMed: 7513427DOI: 10.1073/pnas.91.9.3911 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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