1T25
Plasmodium falciparum lactate dehydrogenase complexed with NADH and 3-hydroxyisoxazole-4-carboxylic acid
Summary for 1T25
Entry DOI | 10.2210/pdb1t25/pdb |
Related | 1LDG 1T24 1T26 1T2C 1T2D 1T2E 1T2F |
Descriptor | L-lactate dehydrogenase, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3-HYDROXYISOXAZOLE-4-CARBOXYLIC ACID, ... (5 entities in total) |
Functional Keywords | protein-ligand complex, oxidoreductase |
Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
Total number of polymer chains | 1 |
Total formula weight | 35864.19 |
Authors | Cameron, A.,Read, J.,Tranter, R.,Winter, V.J.,Sessions, R.B.,Brady, R.L.,Vivas, L.,Easton, A.,Kendrick, H.,Croft, S.L.,Barros, D.,Lavandera, J.L.,Martin, J.J.,Risco, F.,Garcia-Ochoa, S.,Gamo, F.J.,Sanz, L.,Leon, L.,Ruiz, J.R.,Gabarro, R.,Mallo, A.,De Las Heras, F.G. (deposition date: 2004-04-20, release date: 2004-05-11, Last modification date: 2023-08-23) |
Primary citation | Cameron, A.,Read, J.,Tranter, R.,Winter, V.J.,Sessions, R.B.,Brady, R.L.,Vivas, L.,Easton, A.,Kendrick, H.,Croft, S.L.,Barros, D.,Lavandera, J.L.,Martin, J.J.,Risco, F.,Garcia-Ochoa, S.,Gamo, F.J.,Sanz, L.,Leon, L.,Ruiz, J.R.,Gabarro, R.,Mallo, A.,De Las Heras, F.G. Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. J.Biol.Chem., 279:31429-31439, 2004 Cited by PubMed: 15117937DOI: 10.1074/jbc.M402433200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report