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1T25

Plasmodium falciparum lactate dehydrogenase complexed with NADH and 3-hydroxyisoxazole-4-carboxylic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004459molecular_functionL-lactate dehydrogenase activity
A0006089biological_processlactate metabolic process
A0006090biological_processpyruvate metabolic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019752biological_processcarboxylic acid metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues32
DetailsBINDING SITE FOR RESIDUE NAI A 336
ChainResidue
AGLY27
ATHR97
AALA98
AGLY99
APHE100
ATHR101
ALEU112
AVAL138
AASN140
AVAL142
ALEU163
AGLY29
ALEU167
AHIS195
AGAG337
AHOH484
AHOH488
AHOH495
AHOH546
AHOH558
AHOH559
AHOH560
AMET30
AHOH562
AHOH563
AHOH566
AILE31
APHE52
AASP53
AILE54
AVAL55
ATYR85

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GAG A 337
ChainResidue
AARG109
AASN140
AARG171
AHIS195
AALA236
ASER245
APRO246
ANAI336
AHOH484

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL A 401
ChainResidue
ATHR169
ALYS173
AASN188
AALA189
AGLY209
AVAL268
AILE270
AHOH405
AHOH448
AHOH453

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AHIS195

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING:
ChainResidueDetails
AMET30
ALEU163
AARG171
AHIS195
AILE31
AASP53
ATYR85
AGLY99
APHE100
AARG109
AVAL138
AASN140

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1emd
ChainResidueDetails
AHIS195
AASP168

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1emd
ChainResidueDetails
AHIS195
AARG171
AASP168

222415

PDB entries from 2024-07-10

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