1T24

Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid

Summary for 1T24

Entry DOI	10.2210/pdb1t24/pdb
Related	1LDG 1T25 1T26 1T2C 1T2D 1T2E 1T2F
Descriptor	L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID, ... (5 entities in total)
Functional Keywords	protein-ligand complex, oxidoreductase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	1
Total formula weight	35863.16
Authors	Cameron, A.,Read, J.,Tranter, R.,Winter, V.J.,Sessions, R.B.,Brady, R.L.,Vivas, L.,Easton, A.,Kendrick, H.,Croft, S.L.,Barros, D.,Lavandera, J.L.,Martin, J.J.,Risco, F.,Garcia-Ochoa, S.,Gamo, F.J.,Sanz, L.,Leon, L.,Ruiz, J.R.,Gabarro, R.,Mallo, A.,De Las Heras, F.G. (deposition date: 2004-04-20, release date: 2004-05-11, Last modification date: 2023-08-23)
Primary citation	Cameron, A.,Read, J.,Tranter, R.,Winter, V.J.,Sessions, R.B.,Brady, R.L.,Vivas, L.,Easton, A.,Kendrick, H.,Croft, S.L.,Barros, D.,Lavandera, J.L.,Martin, J.J.,Risco, F.,Garcia-Ochoa, S.,Gamo, F.J.,Sanz, L.,Leon, L.,Ruiz, J.R.,Gabarro, R.,Mallo, A.,De Las Heras, F.G. Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity. J.Biol.Chem., 279:31429-31439, 2004 Cited by PubMed: 15117937 DOI: 10.1074/jbc.M402433200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation