1M4H
Crystal Structure of Beta-secretase complexed with Inhibitor OM00-3
Summary for 1M4H
| Entry DOI | 10.2210/pdb1m4h/pdb |
| Related PRD ID | PRD_000289 |
| Descriptor | beta-Secretase, Inhibitor OM00-3 (3 entities in total) |
| Functional Keywords | memapsin2, base, asp2, alzheimer's disease, aspartic protease, acid protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) More |
| Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
| Total number of polymer chains | 4 |
| Total formula weight | 89126.50 |
| Authors | Hong, L.,Turner, R.T.,Koelsch, G.,Ghosh, A.K.,Tang, J. (deposition date: 2002-07-02, release date: 2002-08-28, Last modification date: 2023-11-15) |
| Primary citation | Hong, L.,Turner, R.T.,Koelsch, G.,Shin, D.,Ghosh, A.K.,Tang, J. Crystal Structure of Memapsin 2 (beta-Secretase) in Complex with Inhibitor OM00-3 Biochemistry, 41:10963-10967, 2002 Cited by PubMed: 12206667DOI: 10.1021/bi026232n PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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