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1M2Z

Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif

Summary for 1M2Z
Entry DOI10.2210/pdb1m2z/pdb
Descriptorglucocorticoid receptor, nuclear receptor coactivator 2, octyl beta-D-glucopyranoside, ... (5 entities in total)
Functional Keywordsglucocorticoid receptor, dexamethasone, tif2, dimer interface, hormone binding pocket, charge clamp, coactivator, hormone-hormone activator complex, hormone/hormone activator
Biological sourceHomo sapiens (human)
More
Total number of polymer chains4
Total formula weight66183.12
Authors
Primary citationBledsoe, R.B.,Montana, V.G.,Stanley, T.B.,Delves, C.J.,Apolito, C.J.,Mckee, D.D.,Consler, T.G.,Parks, D.J.,Stewart, E.L.,Willson, T.M.,Lambert, M.H.,Moore, J.T.,Pearce, K.H.,Xu, H.E.
Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition
Cell(Cambridge,Mass.), 110:93-105, 2002
Cited by
PubMed: 12151000
DOI: 10.1016/S0092-8674(02)00817-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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