1M2Z
Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | glucocorticoid receptor | polymer | 257 | 29811.7 | 2 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR |
| 2 | B, D (B, E) | nuclear receptor coactivator 2 | polymer | 21 | 2448.8 | 2 | UniProt (Q15596) | Transcriptional intermediary factor 2, TIF2 | |
| 3 | E, F, G (A) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 3 | Chemie (BOG) | |||
| 4 | H, I (A, D) | DEXAMETHASONE | non-polymer | 392.5 | 2 | Chemie (DEX) PubChem (16757640) PubChem (21140858) PubChem (3003) PubChem (176476476) PubChem (176476477) PubChem (176481066) PubChem (176519880) PubChem (176541415) PubChem (5743) PubChem (24758428) PubChem (24848023) PubChem (40467076) PubChem (40469527) PubChem (40469528) PubChem (40469529) PubChem (40469538) PubChem (40469540) PubChem (18609236) PubChem (46870667) PubChem (134645) PubChem (146915) PubChem (51529018) PubChem (51723203) PubChem (51723204) PubChem (53316140) PubChem (56627169) PubChem (40467075) PubChem (57959704) PubChem (57959709) PubChem (59499751) PubChem (59553041) PubChem (45791747) PubChem (60032782) PubChem (60107679) PubChem (60107685) PubChem (60113881) PubChem (60129028) PubChem (66739593) PubChem (67968282) PubChem (68163950) PubChem (68346426) PubChem (69301933) PubChem (70211292) PubChem (70834467) PubChem (70965822) PubChem (71083129) PubChem (51654720) PubChem (451600) PubChem (469455) PubChem (656865) PubChem (73707402) PubChem (73945193) PubChem (73950719) PubChem (1150209) PubChem (1426961) PubChem (68625576) PubChem (176476478) PubChem (3036635) PubChem (90141965) PubChem (9782) PubChem (155299) PubChem (71299643) PubChem (969487) PubChem (92043418) PubChem (92259599) PubChem (5702012) PubChem (6432476) PubChem (6546942) PubChem (6604243) PubChem (6603742) PubChem (124301806) PubChem (5702035) PubChem (92259552) PubChem (6610297) PubChem (6610335) PubChem (6710614) PubChem (117072391) PubChem (9830630) PubChem (9865316) PubChem (123132537) PubChem (124190915) PubChem (11014684) PubChem (124304345) PubChem (12358596) PubChem (12358597) PubChem (12358599) PubChem (12358600) PubChem (12358601) PubChem (12358603) PubChem (14697793) PubChem (124904342) PubChem (124904343) PubChem (124918510) PubChem (124918511) PubChem (129010233) PubChem (133634290) PubChem (133645861) PubChem (134990893) PubChem (135396701) PubChem (137704752) PubChem (139404989) PubChem (140662068) PubChem (145705940) PubChem (146436354) PubChem (152964101) PubChem (162730335) PubChem (163285078) PubChem (163285103) PubChem (164010962) PubChem (175434953) PubChem (176282643) | |||
| 5 | J, K, L, M (A, B, D, E) | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A, D: 521 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 602 | Phe 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64521.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1662.0 | |
| All* | Total formula weight | 66183.1 |
