1M2Z
Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | glucocorticoid receptor | polymer | 257 | 29811.7 | 2 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR |
| 2 | B, D (B, E) | nuclear receptor coactivator 2 | polymer | 21 | 2448.8 | 2 | UniProt (Q15596) | Transcriptional intermediary factor 2, TIF2 | |
| 3 | E, F, G (A) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 3 | Chemie (BOG) | |||
| 4 | H, I (A, D) | DEXAMETHASONE | non-polymer | 392.5 | 2 | Chemie (DEX) | |||
| 5 | J, K, L, M (A, B, D, E) | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A, D: 521 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 602 | Phe 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64521.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1662.0 | |
| All* | Total formula weight | 66183.1 |
