1COS

CRYSTAL STRUCTURE OF A SYNTHETIC TRIPLE-STRANDED ALPHA-HELICAL BUNDLE

Summary for 1COS

Entry DOI	10.2210/pdb1cos/pdb
Descriptor	COILED SERINE (2 entities in total)
Functional Keywords	alpha-helical bundle
Total number of polymer chains	3
Total formula weight	10007.59
Authors	Lovejoy, B.,Choe, S.,Cascio, D.,Mcrorie, D.K.,Degrado, W.,Eisenberg, D. (deposition date: 1993-01-22, release date: 1993-10-31, Last modification date: 2024-11-06)
Primary citation	Lovejoy, B.,Choe, S.,Cascio, D.,McRorie, D.K.,DeGrado, W.F.,Eisenberg, D. Crystal structure of a synthetic triple-stranded alpha-helical bundle. Science, 259:1288-1293, 1993 Cited by PubMed Abstract: The x-ray crystal structure of a peptide designed to form a double-stranded parallel coiled coil shows that it is actually a triple-stranded coiled coil formed by three alpha-helices. Unlike the designed parallel coiled coil, the helices run up-up-down. The structure is stabilized by a distinctive hydrophobic interface consisting of eight layers. As in the design, each alpha-helix in the coiled coil contributes one leucine side chain to each layer. The structure suggests that hydrophobic interactions are a dominant factor in the stabilization of coiled coils. The stoichiometry and geometry of coiled coils are primarily determined by side chain packing in the solvent-inaccessible interior, but electrostatic interactions also contribute. PubMed: 8446897 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation