1CET
CHLOROQUINE BINDS IN THE COFACTOR BINDING SITE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE.
Summary for 1CET
| Entry DOI | 10.2210/pdb1cet/pdb |
| Descriptor | PROTEIN (L-LACTATE DEHYDROGENASE), N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE (3 entities in total) |
| Functional Keywords | oxidoreductase, tricarboxylic acid cycle, inhibitor |
| Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
| Total number of polymer chains | 1 |
| Total formula weight | 34482.66 |
| Authors | Read, J.A.,Wilkinson, K.W.,Tranter, R.,Sessions, R.B.,Brady, R.L. (deposition date: 1999-03-10, release date: 1999-03-19, Last modification date: 2023-08-09) |
| Primary citation | Read, J.A.,Wilkinson, K.W.,Tranter, R.,Sessions, R.B.,Brady, R.L. Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase. J.Biol.Chem., 274:10213-10218, 1999 Cited by PubMed: 10187806DOI: 10.1074/jbc.274.15.10213 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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