1CET

CHLOROQUINE BINDS IN THE COFACTOR BINDING SITE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE.

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SRS BEAMLINE PX7.2
Synchrotron site	SRS
Beamline	PX7.2
Temperature [K]	100
Detector technology	IMAGE PLATE
Detector	MARRESEARCH
Spacegroup name	I 2 2 2
Unit cell lengths	79.930, 85.440, 92.190
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	20.000 - 2.050
Rwork	0.154
R-free	0.19300
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	1ldg
RMSD bond length	0.006
RMSD bond angle	0.023
Data reduction software	DENZO
Data scaling software	SCALEPACK
Phasing software	AMoRE
Refinement software	X-PLOR (3.851)

Data quality characteristics

	Overall
Low resolution limit [Å]	20.000
High resolution limit [Å]	2.050
Rmerge	0.067
Number of reflections	20155
<I/σ(I)>	16.3
Completeness [%]	99.8
Redundancy	2.3

Crystallization Conditions

crystal ID	method	pH	temperature	details
1		7.5		pH 7.5