1CDW
HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA
Summary for 1CDW
| Entry DOI | 10.2210/pdb1cdw/pdb |
| Descriptor | DNA (5'-D(*CP*TP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*AP*G)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)), ... (4 entities in total) |
| Functional Keywords | transcription initiation, dna binding, complex (transcription factor-dna), transcription-dna complex, transcription/dna |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 3 |
| Total formula weight | 30022.41 |
| Authors | Nikolov, D.B.,Chen, H.,Halay, E.D.,Hoffmann, A.,Roeder, R.G.,Burley, S.K. (deposition date: 1996-04-11, release date: 1996-12-23, Last modification date: 2024-04-03) |
| Primary citation | Nikolov, D.B.,Chen, H.,Halay, E.D.,Hoffman, A.,Roeder, R.G.,Burley, S.K. Crystal structure of a human TATA box-binding protein/TATA element complex. Proc.Natl.Acad.Sci.USA, 93:4862-4867, 1996 Cited by PubMed Abstract: The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box. PubMed: 8643494DOI: 10.1073/pnas.93.10.4862 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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