1BGW
TOPOISOMERASE RESIDUES 410-1202,
Summary for 1BGW
| Entry DOI | 10.2210/pdb1bgw/pdb |
| Descriptor | TOPOISOMERASE (2 entities in total) |
| Functional Keywords | isomerase, topoisomerase, dna-binding, phosphorylated nuclear protein, dna-binding protein, dna binding protein |
| Biological source | Saccharomyces cerevisiae (baker's yeast) |
| Cellular location | Nucleus: P06786 |
| Total number of polymer chains | 1 |
| Total formula weight | 91810.60 |
| Authors | Berger, J.M.,Gamblin, S.J.,Harrison, S.C.,Wang, J.C. (deposition date: 1996-02-20, release date: 1996-07-11, Last modification date: 2024-02-07) |
| Primary citation | Berger, J.M.,Gamblin, S.J.,Harrison, S.C.,Wang, J.C. Structure and mechanism of DNA topoisomerase II. Nature, 379:225-232, 1996 Cited by PubMed Abstract: The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws. PubMed: 8538787DOI: 10.1038/379225a0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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