1BGW

TOPOISOMERASE RESIDUES 410-1202,

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSALS

Chain	Residue	Details
A	LEU448-SER456

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:20485342, ECO:0000269|PubMed:9685374

Chain	Residue	Details
A	TYR783

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:18097402

Chain	Residue	Details
A	GLU450
A	ASP527
A	ASP529

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995

Chain	Residue	Details
A	LYS478
A	TYR735
A	SER741
A	TRP909

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site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000269|PubMed:20485342

Chain	Residue	Details
A	ASN481
A	ARG651
A	LYS652
A	LYS701

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000269|PubMed:20485342

Chain	Residue	Details
A	ARG782

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site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Important for DNA bending; intercalates between base pairs of target DNA => ECO:0000269|PubMed:18097402

Chain	Residue	Details
A	ILE834

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000269|PubMed:1316274

Chain	Residue	Details
A	THR1087

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site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:1316274

Chain	Residue	Details
A	SER1088

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1ab4

Chain	Residue	Details
A	ARG691
A	HIS736
A	TYR783

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