9ZY5

Ca2+ bound gated state Connexin-46

Summary for 9ZY5

• Entry DOI: 10.2210/pdb9zy5/pdb
• Related: 9ZXX 9ZY3
• EMDB information: 74938 74946
• Descriptor: Gap junction alpha-3 protein, CALCIUM ION, 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE (3 entities in total)
• Functional Keywords: calcium regulation, channel gating, connexin, cryo-em, gap junction, large-pore channel, membrane protein
• Biological source: Ovis aries (sheep)
• Total number of polymer chains: 12
• Total formula weight: 634634.81

Authors

Flores, J.A.,O'Neill, S.E.,Jarodsky, J.M.,Reichow, S.L. (deposition date: 2026-01-05, release date: 2026-10-07)

• Primary citation: Flores, J.A.,O'Neill, S.E.,Jarodsky, J.M.,Haddad, B.G.,Reichow, S.L.; Calcium induced N-terminal gating and pore collapse in connexin-46/50 gap junctions; Nat Commun, 2026; DOI: 10.1038/s41467-026-77891-5

Experimental method

ELECTRON MICROSCOPY (2.6 Å)