9ZLG

Crystal structure of DCAF1 in complex with SDIPTAC C9

Summary for 9ZLG

Entry DOI	10.2210/pdb9zlg/pdb
Descriptor	DDB1- and CUL4-associated factor 1, (4P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide, (4P,4'P)-5,5'-[(1E,36E)-3,35-dioxo-7,10,13,16,19,22,25,28,31-nonaoxa-4,34-diazaheptatriaconta-1,36-diene-1,37-diyl]bis{N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide}, ... (4 entities in total)
Functional Keywords	sdiptac, protac, hiv, e3 ligase, inhibitor, protein binding
Biological source	Homo sapiens (human)
Total number of polymer chains	8
Total formula weight	288914.47
Authors	Mabanglo, M.F.,Srivastava, S.,Hoffer, L.,Ramnauth, J.,Vedadi, M. (deposition date: 2025-12-08, release date: 2026-05-20)
Primary citation	Mabanglo, M.F.,Vedadi, M. Self-dimerization Induced Proximity Targeting Chimeras (SDIPTAC) lead to DCAF1 loss of function and inhibition of HIV replication To Be Published,
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation