9ZL7

Structure of RY12 domain of rabbit RyR1 complexed with ATP and 4-chloro-m-cresol

Summary for 9ZL7

Entry DOI	10.2210/pdb9zl7/pdb
EMDB information	74394
Descriptor	Ryanodine receptor 1, 4-CHLORO-3-METHYLPHENOL, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywords	sarcoplasmic reticulum, intracellular calcium channel, excitation-contraction coupling, complex, membrane protein
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	1
Total formula weight	24456.92
Authors	Kim, K.,Clarke, O.B. (deposition date: 2025-12-08, release date: 2026-09-16)
Primary citation	Kim, K.,Li, H.,Yuan, Q.,Melville, Z.,Zalk, R.,des Georges, A.,Frank, J.,Hendrickson, W.A.,Marks, A.R.,Clarke, O.B. Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene Nat Commun, 2026 Cited by DOI: 10.1038/s41467-026-76519-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.77 Å)

Structure validation