9ZCW

Cryo-EM structure of the engineered vector AAV2.ATX002

This is a non-PDB format compatible entry.

Summary for 9ZCW

• Entry DOI: 10.2210/pdb9zcw/pdb
• EMDB information: 74043
• Descriptor: Engineered AAV2 capsid protein VP3 (1 entity in total)
• Functional Keywords: adeno-associated virus, aav, engineered aav, aav2, virus
• Biological source: adeno-associated virus 2
• Total number of polymer chains: 60
• Total formula weight: 3668411.94

Authors

Betegon, M.,Byrne, L.C.,Conway, J.F. (deposition date: 2025-11-24, release date: 2026-04-01)

• Primary citation: Johnson, M.E.,Ozturk, B.E.,Tugwell, T.H.,Lambros, M.,Janowitz, H.,Sedorovitz, M.,Flohr, K.,Campello, L.,Hartung, J.E.,Hogle, B.,Gillespie, M.,Schriever, H.,Aweidah, H.,Koester, J.,Clausen, I.,Seeber, S.,Revelant, F.,Schreurs, R.,Koechl, F.,Sieving, P.A.,Sahel, J.A.,Stauffer, W.R.,Peixoto, R.T.,Fauser, S.,Lin, R.,Conway, J.,Da Silva, S.,Krol, J.,Betegon, M.,Byrne, L.C.; Structural dynamics insights into principles underlying the increased fitness of newly engineered and broadly potent AAV capsids; To Be Published,

Experimental method

ELECTRON MICROSCOPY (1.9 Å)