9ZCV

Human TRPM8 fully-swapped, desensitized, ligand-free structure at 4 degrees Celsius resolved in cell vesicles

Summary for 9ZCV

• Entry DOI: 10.2210/pdb9zcv/pdb
• EMDB information: 74042
• Descriptor: Transient receptor potential cation channel subfamily M member 8 (1 entity in total)
• Functional Keywords: trpm8, transient receptor potential melastatin 8, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 513336.88

Authors

Choi, K.Y.,Lin, X.,Cheng, Y.,Julius, D. (deposition date: 2025-11-24, release date: 2026-03-25)

• Primary citation: Choi, K.Y.,Lin, X.,Cheng, Y.,Julius, D.; Structural energetics of cold sensitivity; Nature, 2026; DOI: 10.1038/s41586-026-10276-2

Experimental method

ELECTRON MICROSCOPY (3.65 Å)