9ZCR

Parus major TRPM8 with a chimeric human outer pore loops, semi-swapped, ligand-free, cold, structure resolved in GDN

Summary for 9ZCR

• Entry DOI: 10.2210/pdb9zcr/pdb
• EMDB information: 74040
• Descriptor: Transient receptor potential cation channel subfamily M member 8 (1 entity in total)
• Functional Keywords: trpm8, transient receptor potential melastatin 8, membrane protein, human
• Biological source: Parus major (Great Tit)
• Total number of polymer chains: 4
• Total formula weight: 508520.06

Authors

Choi, K.Y.,Lin, X.,Cheng, Y.,Julius, D. (deposition date: 2025-11-24, release date: 2026-03-25)

• Primary citation: Choi, K.Y.,Lin, X.,Cheng, Y.,Julius, D.; Structural energetics of cold sensitivity; Nature, 2026; DOI: 10.1038/s41586-026-10276-2

Experimental method

ELECTRON MICROSCOPY (3.07 Å)