9ZCQ

Avian TRPM8 (Parus major) semi-swapped, closed, calcium free, menthol bound structure resolved in cell vesicles

Summary for 9ZCQ

• Entry DOI: 10.2210/pdb9zcq/pdb
• EMDB information: 74039
• Descriptor: Transient receptor potential cation channel subfamily M member 8, (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol (2 entities in total)
• Functional Keywords: trpm8, transient receptor potential melastatin 8, membrane protein, menthol
• Biological source: Parus major (Great Tit)
• Total number of polymer chains: 4
• Total formula weight: 509493.12

Authors

Choi, K.Y.,Lin, X.,Cheng, Y.,Julius, D. (deposition date: 2025-11-24, release date: 2026-03-25)

• Primary citation: Choi, K.Y.,Lin, X.,Cheng, Y.,Julius, D.; Structural energetics of cold sensitivity; Nature, 2026; DOI: 10.1038/s41586-026-10276-2

Experimental method

ELECTRON MICROSCOPY (3.57 Å)