9ZBD

Human GGPPS in the Closed Hexamer Conformation

Summary for 9ZBD

• Entry DOI: 10.2210/pdb9zbd/pdb
• Related: 9ZB9 9ZBC
• EMDB information: 73979 73983
• Descriptor: Geranylgeranyl pyrophosphate synthase (1 entity in total)
• Functional Keywords: inhibitor, complex, isoprenoid, synthesis, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 209837.30

Authors

Ferens, F.G.,Tsantrizos, Y.S.,Lemieux, M.J. (deposition date: 2025-11-20, release date: 2026-09-09, Last modification date: 2026-10-21)

• Primary citation: Ferens, F.G.,Waller, D.D.,Boutin, R.,Lee, H.F.,Tremblay, M.,Saba-El-Leil, M.K.,Guan, T.L.,Skorey, K.,Grignano, E.,Sebag, M.,Wiita, A.P.,Lemieux, M.J.,Tsantrizos, Y.S.; Structural and Functional Analysis of GGPPS Inhibition as a Therapeutic Mechanism for Acute Myeloid Leukemia; J.Med.Chem., 69:21862-21878, 2026; DOI: 10.1021/acs.jmedchem.6c00808

Experimental method

ELECTRON MICROSCOPY (2.36 Å)