9ZBA

Human GGPPS Bound to Selective Inhibitor CML-07-119 in theShielded Binding Site Conformation

This is a non-PDB format compatible entry.

Summary for 9ZBA

• Entry DOI: 10.2210/pdb9zba/pdb
• Related: 9ZB9
• EMDB information: 73980
• Descriptor: Geranylgeranyl pyrophosphate synthase, {[(2-{3-[(3-fluoro-4-methoxyphenyl)carbamoyl]phenyl}thieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic acid), MAGNESIUM ION (3 entities in total)
• Functional Keywords: inhibitor, complex, isoprenoid, synthesis, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35614.21

Authors

Ferens, F.G.,Tsantrizos, Y.S.,Lemieux, M.J. (deposition date: 2025-11-20, release date: 2026-09-09)

• Primary citation: Ferens, F.G.,Tsantrizos, Y.S.,Lemieux, M.J.; Human GGPPS Bound to Selective Inhibitor CML-07-119 in the Shielded Binding Site Conformation; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.15 Å)