9ZB9

Cryo-EM Structure of Human GGPPS Bound to Selective Inhibitor CML-07-119

This is a non-PDB format compatible entry.

Summary for 9ZB9

• Entry DOI: 10.2210/pdb9zb9/pdb
• Related: 9ZB8
• EMDB information: 73979
• Descriptor: Geranylgeranyl pyrophosphate synthase, {[(2-{3-[(3-fluoro-4-methoxyphenyl)carbamoyl]phenyl}thieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic acid), MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, isoprenoid, synthesis, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 213685.24

Authors

Ferens, F.G.,Tsantrizos, Y.S.,Lemieux, M.J. (deposition date: 2025-11-20, release date: 2026-09-09)

• Primary citation: Ferens, F.G.,Tsantrizos, Y.S.,Lemieux, M.J.; Cryo-EM Structure of Human GGPPS Bound to Selective Inhibitor CML-07-119; To Be Published,

Experimental method

ELECTRON MICROSCOPY (1.95 Å)