9Z7A

Cryo-EM structure of Secreted extracellular protein A (SepA) from Shigella flexneri complexed with the fragment antigen binding domain of monoclonal antibody 40

This is a non-PDB format compatible entry.

Summary for 9Z7A

• Entry DOI: 10.2210/pdb9z7a/pdb
• EMDB information: 73873
• Descriptor: Serine protease SepA autotransporter, Heavy chain of the fragment antigen binding domain of monoclonal antibody 40, Light chain of the fragment antigen binding domain of monoclonal antibody 40 (3 entities in total)
• Functional Keywords: protease, beta-helix, secreted, monoclonal antibody, hydrolase, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Shigella flexneri 2a str. 2457T; More
• Total number of polymer chains: 3
• Total formula weight: 156691.98

Authors

Buckley, D.P.,Berndsen, Z.T. (deposition date: 2025-11-16, release date: 2026-06-03)

• Primary citation: Buckley, D.P.,Akhtar, M.,Thapa, M.,Schmitz, A.,Turner, J.,Vickers, T.J.,Khatoon, N.,Kaisar, H.,Coggin, J.A.,Ganguli, D.,Sheikh, A.,Laird, R.M.,Poly, F.,Porter, C.K.,Ruiz-Perez, F.,Miller, M.J.,Bhuiyan, T.R.,Qadri, F.,Trillo-Muyo, S.,Dolan, B.,van der Post, S.,Ellebedy, A.,Berndsen, Z.T.,Fleckenstein, J.M.; Human infection with enterotoxigenic E. coli elicits antibodies that broadly neutralize mucin-degrading proteases of pathogenic E. coli and Shigella; To Be Published,

Experimental method

ELECTRON MICROSCOPY (1.99 Å)