9Z74

X-ray structure of SARS-CoV-2 main protease V186G covalently bound to inhibitor Nirmatrelvir at 1.81 A

Summary for 9Z74

• Entry DOI: 10.2210/pdb9z74/pdb
• Descriptor: 3C-like proteinase nsp5, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total)
• Functional Keywords: main protease, 3-chymotrypsin-like protease, mpro, 3clpro, mutant, structural genomics, center for structural biology of infectious diseases, csbid, viral protein, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 1
• Total formula weight: 34285.01

Authors

Beechboard, S.N.,Ghosh, A.K.,Mesecar, A.D.,Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2025-11-16, release date: 2025-11-26)

• Primary citation: Beechboard, S.N.,Ghosh, A.K.,Mesecar, A.D.,Center for Structural Biology of Infectious Diseases (CSBID); X-ray structure of SARS-CoV-2 main protease V186G covalently bound to inhibitor Nirmatrelvir at 1.81 A; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.81 Å)