9Z5Z

Co-crystal structure of compound 3S bound to the Catalytic domain of human PAH

This is a non-PDB format compatible entry.

Summary for 9Z5Z

• Entry DOI: 10.2210/pdb9z5z/pdb
• Descriptor: Phenylalanine-4-hydroxylase, 1-[(4S)-4-(1-benzofuran-2-yl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-3-(1,3-thiazol-2-yl)propan-1-one, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: pah, stabilizer, metal binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 37856.69

Authors

Hammoudeh, D.,Padyana, A. (deposition date: 2025-11-13, release date: 2026-10-21)

• Primary citation: Hammoudeh, D.,Padyana, A.; Discovery of a pharmacological chaperone that stabilizes mutant forms of phenylalanine hydroxylase and significantly lowers blood phenylalanine in a classical phenylketonuria mouse model; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.92 Å)