9Z2W

CryoEM structure of human NSUN2(C271A) with SAH cross-linked to tRNA Lys(TTT) (No D-arm conformation)

This is a non-PDB format compatible entry.

Summary for 9Z2W

• Entry DOI: 10.2210/pdb9z2w/pdb
• EMDB information: 73780
• Descriptor: RNA cytosine C(5)-methyltransferase NSUN2, tRNA Lys(TTT), S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total)
• Functional Keywords: transferase, methyltransferase, trna, complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 113200.52

Authors

Canepa, J.,Ruiz-Arroyo, V.M.,Nam, Y. (deposition date: 2025-11-05, release date: 2026-06-03)

• Primary citation: Canepa, J.,Ruiz-Arroyo, V.M.,Schlamowitz, N.,Nam, Y.; Substrate selectivity of the human RNA m5C methyltransferase NSUN2; Nature, 2026; DOI: 10.1038/s41586-026-10582-9

Experimental method

ELECTRON MICROSCOPY (3.1 Å)