9Z1Y

Cryo-EM structure of human TRPM4 channel in the cold conformation in complex with calcium and TPPO at 37 degrees Celsius (monomeric TMD-focused map with best-resolved TPPO density)

This is a non-PDB format compatible entry.

Summary for 9Z1Y

• Entry DOI: 10.2210/pdb9z1y/pdb
• EMDB information: 73756
• Descriptor: Transient receptor potential cation channel subfamily M member 4, CALCIUM ION, oxotri(phenyl)-lambda~5~-phosphane (3 entities in total)
• Functional Keywords: ion channel, trp channel, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 134774.85

Authors

Jinhong, H.,Wei, L.,Juan, D. (deposition date: 2025-11-04, release date: 2026-06-17)

• Primary citation: Jinhong, H.,Sofia, I.,Sung Jin, P.,Junuk, L.,Jennifer, C.,Garrett, O.,Jiangnan, S.,Juan, D.,Wei, L.; Temperature and intrinsic Ca2+ reshape TRPM4 pharmacology; Nat.Struct.Mol.Biol., 2026; DOI: 10.1038/s41594-026-01818-3

Experimental method

ELECTRON MICROSCOPY (3.26 Å)