9YYH

AI-generated RNA-guided nuclease R-loop formed state

Summary for 9YYH

• Entry DOI: 10.2210/pdb9yyh/pdb
• Related: 9YYG
• EMDB information: 73644 73645
• Descriptor: AI-generated RNA-guided nuclease, RNA (132-MER), DNA (5'-D(P*CP*TP*AP*TP*TP*GP*AP*T)-3'), ... (5 entities in total)
• Functional Keywords: crispr, nuclease, ai, evolution scale modeling, inverse folding, esm-if1, tnpb, tam, pam, spacer, exonuclease, dna binding protein-dna complex, enzyme, ribonucleoprotein, rna, rna-guided nuclease, cas12, isdra2, esm, rna binding protein
• Biological source: synthetic construct; More
• Total number of polymer chains: 5
• Total formula weight: 98928.43

Authors

Skopintsev, P.,Esain-Garcia, I.,Doudna, J. (deposition date: 2025-10-29, release date: 2026-07-15)

• Primary citation: Skopintsev, P.,Esain-Garcia, I.,Doudna, J.; Structure and evolution-guided design of minimal RNA-guided nucleases; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.8 Å)