9YSN

Human DCTPP1 bound to a Class I inhibitor

This is a non-PDB format compatible entry.

Summary for 9YSN

• Entry DOI: 10.2210/pdb9ysn/pdb
• Descriptor: dCTP pyrophosphatase 1, 2-{[7-(4-cyclohexylpiperazin-1-yl)-4-nitro-2,1,3-benzoxadiazol-5-yl]amino}ethan-1-ol, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: inhibitor, pyrophosphatase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 104760.37

Authors

Hauk, G.,Berger, J.M. (deposition date: 2025-10-19, release date: 2026-06-10)

• Primary citation: Hauk, G.,Liu, J.,Nelson, W.G.,Yegnasubramanian, S.,Berger, J.M.; Structural insights into novel DCTPP1 antagonists and their synergistic action with DNMT inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)