9YR6

Structure of HTTQ23-HAP40 complex bound to a small molecule ligand

This is a non-PDB format compatible entry.

Summary for 9YR6

• Entry DOI: 10.2210/pdb9yr6/pdb
• EMDB information: 73361
• Descriptor: Huntingtin, 40-kDa huntingtin-associated protein, 2-[(1R)-2,2-difluorocyclopropyl]-N-[(1-methyl-1H-indazol-6-yl)methyl]aniline (3 entities in total)
• Functional Keywords: huntingtin, polyglutamine expansion, small molecule ligand, ligand discovery, peptide binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 391127.94

Authors

Balakrishnan, S.,Deme, J.,Lea, S.M.,Harding, R.J. (deposition date: 2025-10-16, release date: 2025-12-03)

• Primary citation: Balakrishnan, S.,Deme, J.,Lea, S.M.,Harding, R.J.; Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex; Biorxiv, 2025; DOI: 10.1101/2025.11.21.689733v1

Experimental method

ELECTRON MICROSCOPY (2.3 Å)