9YP4

Cryo-EM structure of human beta-cardiac myosin bound to omecamtiv mecarbil in the interacting-heads motif and S2-FH docked state

This is a non-PDB format compatible entry.

Summary for 9YP4

• Entry DOI: 10.2210/pdb9yp4/pdb
• EMDB information: 73283
• Descriptor: Myosin-7,General control transcription factor GCN4,Enhanced Green fluorescent protein, Myosin light chain 1/3, skeletal muscle isoform, Myosin regulatory light chain 11, ... (6 entities in total)
• Functional Keywords: cardiac myosin, interacting heads motif, omecamtiv mecarbil, actin binding, contractile protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 382358.08

Authors

Somavarapu, A.K.,Craig, R.,Padron, R. (deposition date: 2025-10-13, release date: 2026-04-08)

• Primary citation: Somavarapu, A.K.,Ge, J.,Yengo, C.M.,Craig, R.,Padron, R.; Cryo-EM Reveals How Cardiomyopathy Therapeutic Drugs Modulate the Myosin Motors of the Heart; to be published,

Experimental method

ELECTRON MICROSCOPY (4.5 Å)