9YKO

Crystal structure of human DYRK1A kinase bound with inhibitor FC3

This is a non-PDB format compatible entry.

Summary for 9YKO

• Entry DOI: 10.2210/pdb9yko/pdb
• Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, (5,6-dihydroxy-1,3-benzothiazol-2-yl)(3,4-dihydroxyphenyl)methanone (3 entities in total)
• Functional Keywords: kinase, inhibitor, co-crystallization, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 168666.21

Authors

Elkayam, E.,Garg, A.,Joshua-Tor, L. (deposition date: 2025-10-07, release date: 2026-06-17)

• Primary citation: Venkataramani, P.,Elkayam, E.,Garg, A.,Cheng, K.F.,Altiti, A.,He, M.,Thakur, K.,Michalopoulou, E.,Gonzalez, C.,Felice, C.,Van Aelst, L.,Pappin, D.,Joshua-Tor, L.,Al-Abed, Y.,Tonks, N.K.; Small-molecule inhibitors of the protein kinase DYRK as potential therapeutic candidates in cancer; Cell Chem Biol, 2026; DOI: 10.1016/j.chembiol.2026.05.005

Experimental method

X-RAY DIFFRACTION (2.77 Å)