9YG0

Targeting PTPN22 at non-orthosteric binding sites - a fragment approach

This is a non-PDB format compatible entry.

Summary for 9YG0

• Entry DOI: 10.2210/pdb9yg0/pdb
• Related: 9YDM
• Descriptor: Tyrosine-protein phosphatase non-receptor type 22, GLYCEROL, ETHANOL, ... (7 entities in total)
• Functional Keywords: non-receptor protein tyrosine phosphatase, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 153292.57

Authors

Di Lello, P.,Wells, M.M. (deposition date: 2025-09-27, release date: 2026-01-28)

• Primary citation: Di Lello, P.,Wells, M.M.,Davis, B.,Daniels, Z.,Garner, T.P.,Gazzard, L.,Harris, R.,Hubbard, R.E.,Landry, M.L.,Martin, B.,Morgan, J.L.W.,Patapoff, A.,Simmonite, H.,Skelton, N.,Ultsch, M.,Walters, B.T.,Wu, P.,Dimitrova, Y.N.,Huard, K.; Targeting PTPN22 at Nonorthosteric Binding Sites - A Fragment Approach; Acs Omega, 11:3465-3480, 2026; DOI: 10.1021/acsomega.5c11028

Experimental method

X-RAY DIFFRACTION (1.76 Å)