9YC8

Leucine Rich Repeat Kinase 2 activate state (Apo ROC state 1)

Summary for 9YC8

Entry DOI	10.2210/pdb9yc8/pdb
EMDB information	72762
Descriptor	Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION (2 entities in total)
Functional Keywords	kinase, gtpases, lrrk2, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	286487.09
Authors	Villagran Suarez, A.,Bodrug, T.,Leschziner, A. (deposition date: 2025-09-18, release date: 2026-08-19)
Primary citation	Villagran Suarez, A.,Hatch, K.S.,Bodrug, T.,Gai, W.,Surridge, K.J.,Moussikhina, E.,Nguyen, K.H.,Sanz-Murillo, M.,Callahan, R.,Xiong, E.,Ramos, D.,Zhu, L.,Dederer, V.,Mathea, S.,Iwasa, J.,Knapp, S.,Shokat, K.M.,Reck-Peterson, S.L.,Leschziner, A.E. The structural basis for LRRK2's activation and autoinhibition Cell(Cambridge,Mass.), 2026 Cited by DOI: 10.1016/j.cell.2026.07.027 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.02 Å)

Structure validation