9YBL

LRRK2 asymmetric dimer

Summary for 9YBL

• Entry DOI: 10.2210/pdb9ybl/pdb
• EMDB information: 72751
• Descriptor: Leucine-rich repeat serine/threonine-protein kinase 2, GUANOSINE-5'-DIPHOSPHATE (2 entities in total)
• Functional Keywords: kinase, gtpases, lrrk2, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 573368.76

Authors

Villagran Suarez, A.,Bodrug, T.,Leschziner, A. (deposition date: 2025-09-17, release date: 2026-08-19)

• Primary citation: Villagran Suarez, A.,Hatch, K.S.,Bodrug, T.,Gai, W.,Surridge, K.J.,Moussikhina, E.,Nguyen, K.H.,Sanz-Murillo, M.,Callahan, R.,Xiong, E.,Ramos, D.,Zhu, L.,Dederer, V.,Mathea, S.,Iwasa, J.,Knapp, S.,Shokat, K.M.,Reck-Peterson, S.L.,Leschziner, A.E.; The structural basis for LRRK2's activation and autoinhibition; Cell(Cambridge,Mass.), 2026; DOI: 10.1016/j.cell.2026.07.027

Experimental method

ELECTRON MICROSCOPY (3.44 Å)