9Y8W

MERS Mpro with EGT710

This is a non-PDB format compatible entry.

Summary for 9Y8W

• Entry DOI: 10.2210/pdb9y8w/pdb
• Descriptor: 3C-like proteinase nsp5, (4S)-4-(iminomethyl)-3-(isoquinolin-4-yl)-1-[6-(trifluoromethyl)pyridin-3-yl]imidazolidin-2-one (3 entities in total)
• Functional Keywords: mpro mers covid, hydrolase
• Biological source: Middle East respiratory syndrome-related coronavirus
• Total number of polymer chains: 4
• Total formula weight: 134958.06

Authors

Knapp, M.S.,Ornelas, E. (deposition date: 2025-09-11, release date: 2025-12-24)

• Primary citation: Moquin, S.A.,Lakshminarayana, S.B.,Balavenkatraman, K.K.,Schiller, H.,Claas, A.,Bhhatarai, B.,Loisios-Konstantinidis, I.,Vulic, K.,Kurhade, C.,Kalveram, B.K.,Chen, J.Y.C.,Zou, J.,Xie, X.,Tandeske, L.,Dovala, D.,Ornelas, E.,Knapp, M.S.,Fuller, D.,Nguyen, Z.,Barkan, D.T.,Bebrevska, L.,Wright, S.K.,Busby, S.A.,Blais, J.,Shi, P.Y.,Gaudet, S.,Bergeron, R.,Yu, H.,Zack, J.,Sarko, C.,Gu, F.,Bradner, J.E.,Tallarico, J.A.,Diagana, T.T.,Papillon, J.P.N.; Preclinical characterization of EGT710, an oral non-peptidomimetic reversible covalent SARS-CoV-2 main protease inhibitor; Npj Drug Discov, 2:28-, 2025; DOI: 10.1038/s44386-025-00030-5

Experimental method

X-RAY DIFFRACTION (3.04 Å)