9Y75

Cryo-EM structure of ML-SA1-bound full-length mouse TRPML2 channel in lipid nanodisc, closed IV

Summary for 9Y75

• Entry DOI: 10.2210/pdb9y75/pdb
• EMDB information: 72643
• Descriptor: Mucolipin-2, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione (2 entities in total)
• Functional Keywords: cation channel, membrane protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 263532.10

Authors

Park, S.,Yang, J. (deposition date: 2025-09-09, release date: 2026-09-16)

• Primary citation: Park, S.,Yang, J.; Conformational landscape of synergistic activation of mouse TRPML2 channel; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.47 Å)