9Y5S

eIF2B lacking the latch helix bound to ISRACT-01 (Inactive state)

This is a non-PDB format compatible entry.

Summary for 9Y5S

• Entry DOI: 10.2210/pdb9y5s/pdb
• EMDB information: 72462 72463 72466 72467 72468 72477 72499 72520 72521
• Descriptor: Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... (9 entities in total)
• Functional Keywords: guanine nucleotide exchange factor, gef, translation, initiation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 524416.95

Authors

Dalwadi, U.,Croll, T.,Subramanian, A.,Lee, D.J.,Arthur, C.,Walter, P.,Frost, A. (deposition date: 2025-09-05, release date: 2026-07-08)

• Primary citation: Dalwadi, U.,Subramanian, A.,Deal, A.,Conrad, J.E.,Nadjsombati, T.,Venkatesh, M.,Boone, M.,Egea, P.F.,He, L.,Jain, N.,Lee, D.J.,Liu, Y.,Reineke, L.C.,Saito, K.,Talledge, N.,Toutkoushian, H.,Le Vasseur, M.,Zappa, F.,de Groot, R.J.,Acosta-Alvear, D.,Arthur, C.P.,Nunnari, J.,Marqusee, S.,Lawrence, R.E.,Costa-Mattioli, M.,Crawford, J.J.,van Kuppeveld, F.J.M.,Croll, T.I.,Walter, P.,Frost, A.; Allosteric disordering of eIF2B regulates the integrated stress response; Nat.Chem.Biol., 2026; DOI: 10.1038/s41589-026-02256-4

Experimental method

ELECTRON MICROSCOPY (3.1 Å)