9Y5C

Chimeric antibody 2C7 Fab fragment against gonococcal lipooligosaccharide bound to octasaccharide antigen

Summary for 9Y5C

• Entry DOI: 10.2210/pdb9y5c/pdb
• Descriptor: Fab heavy chain, Fab lambda light chain, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose-(1-3)-[2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)]L-glycero-alpha-D-manno-heptopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-beta-D-glucopyranose-(1-4)]L-glycero-alpha-D-manno-heptopyranose-(1-5)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, ... (6 entities in total)
• Functional Keywords: antibody, fab fragment, oligosaccharide, antigen, immune system
• Biological source: Mus musculus; More
• Total number of polymer chains: 4
• Total formula weight: 96413.44

Authors

Beernink, P.T.,Silipo, A.,Rice, P.A.,Ram, S. (deposition date: 2025-09-04, release date: 2026-11-04)

• Primary citation: Tsagkarakou, A.S.,Nieto-Fabregat, F.,Masi, A.,Zhang, Y.,Fan, F.,Shaughnessy, J.,Rice, P.A.,Huang, X.,Ram, S.,Beernink, P.T.,Silipo, A.; Structural Basis for Recognition of a Gonococcal Lipooligosaccharide Epitope by Monoclonal Antibody 2C7 Informs Vaccine and Immunotherapeutic Design; Jacs Au, 2026; DOI: 10.1021/jacsau.6c01227

Experimental method

X-RAY DIFFRACTION (1.6 Å)