9Y0H

Insulin Degrading Enzyme Time-resolved O/O state

Summary for 9Y0H

• Entry DOI: 10.2210/pdb9y0h/pdb
• Related: 7RZE 7RZF 7RZG 7RZH 7RZI
• EMDB information: 72393
• Descriptor: Cysteine-free Insulin-degrading enzyme (1 entity in total)
• Functional Keywords: m16a zinc metalloprotease, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 234137.02

Authors

Mancl, J.M.,Tang, W.J. (deposition date: 2025-08-28, release date: 2026-05-06)

• Primary citation: Mancl, J.M.,Liang, W.G.,Wei, H.,Carragher, B.,Potter, C.S.,Tang, W.J.; Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity; eLife, 2025; DOI: 10.7554/eLife.105761.1

Experimental method

ELECTRON MICROSCOPY (5.1 Å)