9XZ2

Crystal structure of BTK kinase domain bound to a tirabrutinib analog with an acrylamide warhead

This is a non-PDB format compatible entry.

Summary for 9XZ2

• Entry DOI: 10.2210/pdb9xz2/pdb
• Related: 9XYV 9XYY
• Descriptor: Tyrosine-protein kinase BTK, 6-amino-7-(4-phenoxyphenyl)-9-[(3R)-1-propanoylpyrrolidin-3-yl]-7,9-dihydro-8H-purin-8-one (2 entities in total)
• Functional Keywords: inhibitor, kinase, complex, covalent, transferase-transferase inhibitor complex, transferase
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 64532.01

Authors

Lin, D.Y.,Joseph, R.E.,Andreotti, A.H. (deposition date: 2025-08-26, release date: 2026-09-09)

• Primary citation: Lin, D.Y.,Joseph, R.E.,Andreotti, A.H.; Crystal structure of BTK kinase domain bound to a tirabrutinib analog with an acrylamide warhead; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.48 Å)