9XJQ

Crystal structure of human WDR5 in complex with KMS01

This is a non-PDB format compatible entry.

Summary for 9XJQ

• Entry DOI: 10.2210/pdb9xjq/pdb
• Descriptor: WD repeat-containing protein 5, 2,4-bis(chloranyl)-~{N}-(5-ethynylthiophen-2-yl)sulfonyl-benzamide (3 entities in total)
• Functional Keywords: cancer, wd-repeat, drug discovery, wbm site, dna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 33852.26

Authors

Cao, Y.,Zhang, X.L.,Bai, F. (deposition date: 2025-11-05, release date: 2026-11-11)

• Primary citation: Cao, Y.,Han, Q.L.,Ren, P.X.,Bai, F.; Dual Targeting of WDR5 and RBM39 Unveils a Promising Therapeutic Vulnerability in MYCN-Driven Neuroblastoma; To be published,

Experimental method

X-RAY DIFFRACTION (1.51 Å)