9XGI

First-generation 2N4R human tau filaments seeded by Alzheimer's disease tau

Summary for 9XGI

• Entry DOI: 10.2210/pdb9xgi/pdb
• EMDB information: 66848
• Descriptor: Isoform Tau-F of Microtubule-associated protein tau (1 entity in total)
• Functional Keywords: recombinant human full length tau, seeded from alzheimer's disease patient, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 137759.61

Authors

Zeng, W.,Sun, S.,Shi, Y.,He, Z. (deposition date: 2025-10-30, release date: 2026-11-04)

• Primary citation: Zeng, W.,Sun, S.,Li, Q.,Sun, Z.,Hu, Y.,Duan, J.,Zhao, B.,Zheng, H.,EunRan, S.,Vivianna, M.V.D.,Xu, P.,Yu, B.,Qiu, H.,Yuan, W.,Shi, Y.,He, Z.; Golgi-derived glycosaminoglycans are involved in pathological tau seeds formation as the cofactor in Alzheimer's disease and related tauopathies; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.88 Å)