9XEG

Structure of the Mid-Cap-627 linker domains of the H5N1 influenza A PB2 subunit in complex with onradivir

This is a non-PDB format compatible entry.

Summary for 9XEG

• Entry DOI: 10.2210/pdb9xeg/pdb
• Descriptor: Polymerase basic protein 2, GLYCEROL, (2~{S},3~{S})-3-[[6-cyclopropyl-5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, ... (4 entities in total)
• Functional Keywords: influenza virus polymerase, virus, viral protein
• Biological source: Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
• Total number of polymer chains: 1
• Total formula weight: 33043.89

Authors

Gui, J.,Xue, L.,Yang, Z.,Zhong, N.,Xiong, X. (deposition date: 2025-10-28, release date: 2026-06-03)

• Primary citation: Gui, J.,Xue, L.,Yang, Z.,Zhong, N.,Xiong, X.; Structural insights into onoradivir binding to H5N1 influenza virus PB2 protein and its inhibitory mechanism; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.45 Å)