9XAM

The crystal structure of KRAS G12D (GDP bound) in complex with RP03514

This is a non-PDB format compatible entry.

Summary for 9XAM

• Entry DOI: 10.2210/pdb9xam/pdb
• Descriptor: Isoform 2B of GTPase KRas, 5-ethyl-6-fluoranyl-4-[8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]-4-[(4~{S})-1-oxa-8-azaspiro[3.5]nonan-8-yl]pyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 20474.03

Authors

Chen, Z.J.,Jin, W.,Shen, L.Q. (deposition date: 2025-10-22, release date: 2026-08-19)

• Primary citation: Ji, X.,Du, Y.,Zhang, Q.,Zong, B.,Du, K.,He, X.,Wu, G.,Liang, C.,Hu, Q.,Zhang, Y.,Li, H.,Shen, L.,Chen, Z.,Bai, B.,Wang, L.,Ai, J.,Zhang, L.,Zhou, H.,Sun, S.,Wang, Y.,Chang, Z.,Wang, Z.,Chen, D.,Zhou, T.,Kong, X.,Lu, J.; Discovery and Characterization of RP04340: A Highly Potent and Orally Active Pan-KRAS PROTAC Degrader; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c01832

Experimental method

X-RAY DIFFRACTION (1.23 Å)