9X22

Cryo-EM structure of the GLP-1-bound human GLP-1R-Gq complex

Summary for 9X22

• Entry DOI: 10.2210/pdb9x22/pdb
• EMDB information: 66470
• Descriptor: Glucagon-like peptide 1(7-36), Glucagon-like peptide 1 receptor, G subunit q (Gi2-mini-Gq chimeric), ... (5 entities in total)
• Functional Keywords: glp-1r, signaling protein/immune system, signaling protein-immune system complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 129527.51

Authors

Zhou, Q.T.,Zhou, Q.T. (deposition date: 2025-10-03, release date: 2026-03-25)

• Primary citation: Zhou, Q.,Li, J.,Zhang, Y.,Cai, X.,Han, W.,Yang, D.,Wang, M.W.; Distinctive molecular architectures of Gq- and Gi-coupled GLP-1 receptors; Acta Pharm Sin B, 2026; DOI: 10.1016/j.apsb.2026.01.023

Experimental method

ELECTRON MICROSCOPY (2.92 Å)