9X22

Cryo-EM structure of the GLP-1-bound human GLP-1R-Gq complex

Summary for 9X22

Entry DOI	10.2210/pdb9x22/pdb
EMDB information	66470
Descriptor	Glucagon-like peptide 1(7-36), Glucagon-like peptide 1 receptor, G subunit q (Gi2-mini-Gq chimeric), ... (5 entities in total)
Functional Keywords	glp-1r, signaling protein/immune system, signaling protein-immune system complex
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	129527.51
Authors	Zhou, Q.T.,Zhou, Q.T. (deposition date: 2025-10-03, release date: 2026-03-25, Last modification date: 2026-04-15)
Primary citation	Zhou, Q.,Li, J.,Zhang, Y.,Cai, X.,Han, W.,Yang, D.,Wang, M.W. Distinctive molecular architectures of G q - and G i -coupled GLP-1 receptors. Acta Pharm Sin B, 16:1779-1785, 2026 Cited by PubMed: 41909725 DOI: 10.1016/j.apsb.2026.01.023 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.92 Å)

Structure validation